Mesenchymal Stem Cell Based Therapy For Cartilage Repair A Review

4 march 2009 published online.

Mesenchymal stem cell based therapy for cartilage repair a review.

A comprehensive review troy d bornes adetola b adesida and nadr m jomha department of surgery university of alberta laboratory of stem cell biology and orthopaedic tissue engineering edmonton alberta t6g 2e1 canada. Current techniques for cartilage defects repair clinical cartilage repair strategies are required both to prevent the degeneration of cartilage defects into oa and to restore replace the defects. Mesenchymal and stromal cells have also been used for equine cell based cartilage repair. Mesenchymal stem cell msc transplantation has been introduced to avoid some of the side effects and complications of current techniques.

This review intends to highlight the use of mesenchymal stem cells mscs cell based therapy for articular cartilage repair. A review hideyuki koga æ lars engebretsen æ jan e. Mesenchymal stem cell based therapy for cartilage repair. The emergence of the new discipline of regenerative medicine having cell based therapy as its primary focus may enable us to achieve repair and restore the damaged articular cartilage.

Despite progressive advancements in msc manipulation and the introduction of various bioactive scaffolds and growth factors in preclinical studies current clinical trials are still at early stages with preliminary aims to evaluate safety feasibility and efficacy. Mesenchymal stem cell based therapy for cartilage repair. Mesenchymal stem cells in the treatment of traumatic articular cartilage defects. Brinchmann æ takeshi muneta æ ichiro sekiya received.

However the poor ability of cartilage to self repair has motivated efforts to engineer replacement tissues and human mesenchymal stem cells msc which have an extensive proliferation potential. Mesenchymal stem cells mscs have been in the limelight of cell based therapies to promote cartilage repair. A distinct population of chondrocyte progenitor cells exists in the superficial surface zone of articular cartilage 103 117. A review article literature review pdf available in knee surgery sports traumatology arthroscopy 17 11 1289 97 april 2009 with.

The purpose of this paper is to review the literature on msc based cell therapy for articular cartilage repair to determine if it can be an alternative treatment for cartilage injury.