Mesenchymal Stem Cell Rheumatoid Arthritis

The role of mesenchymal stem cells msc in experimental arthritis is undoubtedly conflicting.

Mesenchymal stem cell rheumatoid arthritis.

Mesenchymal stem cell for treatment of rheumatoid arthritis. Mesenchymal stem cells autoimmunity and rheumatoid arthritis j j. Wang l wang l cong x liu g zhou j bai b et al. Rheumatoid arthritis ra is the commonest autoimmune joint disease that has witnessed significant t the vast majority of literature pertaining to mesenchymal stem cells msc immunomodulation has focussed on bone marrow derived msc that are systemically infused to alleviate inflammatory conditions.

They are expected to be a solution for numerous human conditions. This study explored the effect of bone marrow derived msc in previously untested and pathogenetically different models of rheumatoid arthritis ra. However in rheumatoid arthritis ra and spondyloarthritis spa subsets of subchondral bm mscs might conversely fuel synovitis and enthesitis. The purpose of this review is to highlight recent developments and current knowledge gaps in our understanding of the protective effects of mscs against inflammatory arthritis and to discuss their clinical exploitation.

This is a prospective multicenter double blind placebo controlled interventional study to evaluate the safety and efficacy of allogeneic mesenchymal stem cells mscs in 20 patients with new onset rheumatoid arthritis ra. 12 marinova mutafchieva l willimas ro funa k maini rn zwaifler nj. Mcgonagle 1 from the 1 leeds institute of rheumatic and musculoskeletal medicine st. Human umbilical cord mesenchymal stem cell therapy for patients with active rheumatoid arthritis.

Mesenchymal stromal stem cells mscs have potent anti inflammatory and immunomodulatory properties in addition to their ability to form cartilage and bone. El sherbiny 1 2 e a. Jones 1 and d. El jawhari 1 2 y m.

Ra is a systemic autoimmune disorder characterised by aberrant leukocyte infiltration persistent inflammation of synovium and proteases within the joint which ultimately leads to cartilage and bone destruction. James university hospital wtbb ls9 7tf university of leeds uk and 2 clinical pathology department faculty of medicine. Bone marrow mesenchymal stem cells bm mscs can dampen inflammation in animal models of inflammatory rheumatisms and human osteoarthritis.